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Influence of cimetidine on the disposition of ibuprofen in the rat

Parrott, K.A.; Christensen, J.M.

Research Communications in Chemical Pathology and Pharmacology 43(3): 369-380

1984

ISSN/ISBN: 0034-5164
PMID: 6718807
Document Number: 230189
Ibuprofen is a non-steroidal anti-inflammatory agent which is extensively metabolized in both man and the rat. Cimetidine is a well known H2 antagonist which inhibits microsomal enzyme drug metabolism. The influence of cimetidine on the disposition of ibuprofen was studied in Sprague-Dawley rats. Pretreatment with cimetidine increased both the rate and extent of absorption of ibuprofen. Cimetidine treatment also inhibited acidification of gastric fluid. Pretreatment with SKF525A increased ibuprofen half-life but not absorption. Additional studies are necessary to determine the effect of cimetidine on the half-life and absorption of ibuprofen in man.

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