Disposition kinetics of amphotericin B in rats. The influence of dose
Chow, H.H.; Cai, Y.; Mayersohn, M.
Drug Metabolism and Disposition the Biological Fate of Chemicals 20(3): 432-435
1992
ISSN/ISBN: 0090-9556 PMID: 1355720 Document Number: 397255
Amphotericin B (Am-B), an antifungal drug, has been used for the treatment of most disseminated fungal infections. The current therapeutic regimens for this drug are complex, at least in part as a result of limited pharmacokinetic information. In this study, we examined the disposition of Am-B as a function of dose in rats. Groups of male Sprague-Dawley rats were given Am-B by a 15-min iv infusion at three different doses. We observed no significant differences in systemic clearance among the Am-B doses studied (4.29 .+-. 1.42, 3.83 .+-. 0.29, and 3.92 .+-. 0.68 ml/min .cntdot. kg for doses of 0.28, 0.45, and 0.84 mg/kg, respectively). Similarly, small differences were seen in volumes of distribution as a function of dose. We conclude that the disposition kinetics of Am-B were linear over the dose range studied.