Pharmacokinetic investigations of Craviten. II. Dose-dependent elimination kinetics in rats following rapid intravenous injection
Danek, A.; Witek, J.
Polish Journal of Pharmacology and Pharmacy 32(6): 933-939
1980
ISSN/ISBN: 0301-0244 PMID: 7243690 Document Number: 163724
Serum and urine levels of i.v. administered Craviten, an antiarrhythmic, were determined. Comparison of the decline of the same absolute and relative serum concentrations of the drug and the variation of pharmacokinetic parameters with the dose leads to the conclusion that the elimination of Craviten in rats cannot be described by 1st-order kinetics. The amount of the drug found in urine indicates that the fraction of Craviten eliminated in the intact form is .apprx. 1.27% of the i.v. administered dose.