Main pharmacokinetic parameters of p-tyrosol after intravenous injection in rats. Part III: Distribution of p-tyrosol in rat
Chernyshova, G.A.; Plotnikov, M.B.; Smol'iakova, V.I.; Krasnov, E.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(7): 27-29
2011
ISSN/ISBN: 0869-2092 PMID: 21894765 Document Number: 652119
Distribution of p-tyrosol in organism was studied in rats after a single intravenous administration in a dose of 200 mg/kg. It was shown that p-tyrosol rapidly penetrates into well perfused organs (brain, heart, kidneys). The maximum concentration ofp-tyrosol in these organs was determined in 1 minute after administration, and the mean distribution constant was within 0.8-1.11. The albumin bound fraction ofp-tyrozol amounted to 0.26-0.30.