The stereoselectivity of chrono-pharmacokinetic parameters of hydratropic acid in rats
He, Y.S.; Lu, H.L.; Wang, D.Y.; He, S.X.
Yao Xue Xue Bao 28(11): 817-822
1993
ISSN/ISBN: 0513-4870 PMID: 8009998 Document Number: 416916
The stereoselective chrono-pharmacokinetic parameters of hydratropic acid in rats were studied. The results showed that under standard light-dark cycle pharmacokinetic parameters of T-1/2-alpha and CL are stereoselective and under reverse light-dark cycle, parameters T-1/2-beta, AUC, CL, Vc and MRT were shown to be stereoselective. To compare the corresponding parameters of the two different light-dark cycles using t-test, no differences were found in most of them.
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