Autoradiographic investigations of age-dependent proliferation kinetics in the small intestine mucosa of rate
Kranz, D.; Laue, R.; Fuhrmann, I.
Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 124(1-2): 90-98
1980
ISSN/ISBN: 0044-4030 PMID: 7415603 Document Number: 167948
Aging of cells depends on mitotic activity which is particularly evident in multicellular organisms. By means of histoautoradiography we studied the cell kinetics of the mucosa of the small intestine in a total of 244 Wistar rats aged 6 days, 6 weeks, 6, 12, 23 and 28 months, resp. We could demonstrate that the regeneration rate of cells per hour in the crypts of the small intestine and the migration velocity of the enterocytes differ in young and old individuals, and that the intermitotic cells have age-dependent properties as well. In addition, we could prove that intermitotic cells have a nongrowth fraction, too, which at an advanced age, decreases only slightly although significantly in terms of statistics. For the easily vulnerable crypt epithelium it is a reserve capacity and can b included in the proliferating pool if necessary.