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Physicochemical behaviour of isolated DNA and 32P-incorporation in rat tissues following administration of iodine-125

Gupta, G.S.; Chopra, V.K.

Indian Journal of Biochemistry and Biophysics 17(6): 432-437

1980

ISSN/ISBN: 0301-1208
PMID: 7251030
Document Number: 164273
The 32P-incorporation in testis and spleen and the effect of storage on the isolated spleen DNA of rats pre-exposed to 125I for several weeks were studied. Although a considerable decrease of 32P-incorporation in DNA and RNA occurs in testis, spleen shows enhanced incorporation of 32P in DNA and RNA. The studies on optical absorption and viscous flow of DNA indicated base changes and fragmentation on storage of DNA isolated from 125I-treated rats.

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