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Nicotinamide inhibition of 2-14C acetate incorporation into free fatty acids and lipids of rat tissues

Velikii, N.N.; Mogilevich, S.E.; Simonova, N.I.

Ukrainskii Biokhimicheskii Zhurnal 50(3): 368-371

1978

ISSN/ISBN: 0201-8470
PMID: 149405
Document Number: 138160
The synthesis of fatty acids and lipids in the rat tissues is inhibited to a considerable extent during fasting and is activated when feeding highly carobhydrate ration to rats after fasting. Nicotinamide (50 mg/100 g of weight) causes a decrease in intensity of 14C incorporation into free fatty acids and lipids of blood, liver, epididimal and perienal fatty tissues. The degree of nicotinamide inhibition of fatty acids and lipids sythesis is in direct dependence on lipogenesis intensity.

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