Top Abstract Purchase Related
Home
>
Node
>
Subnode

Intensification of the ionophoric effect of polymyxin M by free fatty acids. Dependence of the length of the fatty acid chain

Podgaets, E.R.; Korepanova, E.A.; Vladimirov, I.A.

Biofizika 40(2): 317-322

1995

ISSN/ISBN: 0006-3029
PMID: 7578337
Document Number: 448943
Mechanisms of potentiation of ionophoric effect of polymyxin M by free fatty acids was studied using measurement of electrical properties of bilayer lipid membranes. Among used unsaturated fatty acids the palmitic acid appeared to be the most effective. The obtained dependence of ionophoric effect of membrane antibiotic on the chain length of the fatty acid may be explained by the existence of the complex of special size appropriate to the membrane thickness. We suppose that free fatty acid and polymyxin M form the ion-conducting structure in lipid bilayer.

Document emailed within 1 workday
Secure & encrypted payments

Aust, L.; Bruckner, J.; Levachev, M.M.; Noak, R.; Pokrovskiĭ, A.A. 1978: Effect of fatty acid triglycerides on lipogenesis and the makeup of plasma, fatty tissue and erythocyte membrane fatty acids in rats Voprosy Pitaniia 4: 18-23
Vogelberg, K.H.; Gisbertz, K.H.; Moschinsky, D.; Both, A.; Bostroem, B.; Kübler, W.; Gries, F.A. 1974: Effect of insulin on fatty acid metabolism in the liver in endogenous hypertriglyceridemia. Findings on the uptake of free fatty acids and ketone body production of the liver Verhandlungen der Deutschen Gesellschaft für Innere Medizin 80: 1264-1266
Winkler, L.; Schlag, B.; Goetze, E. 1975: Fatty acid loading capacity of serum albumin in fetal and adult rats when incubating the sera with free fatty acids Acta Biologica et Medica Germanica 34(11-12): 1915-1916
Karagodina, Z.V.; Kulakova, S.N.; Sharanova, N.Ē.; Baturina, V.A.; Soto, S.Kh.; Vasil'ev, A.V. 2011: Relationship between changes in peroxide oxidation lipoide index, coenzyme Q10 and free fatty acids by of rats depending of fatty acid component in the ration Voprosy Pitaniia 80(6): 4-8
Brown, F.R.; Van Duyn, M.A.; Moser, A.B.; Schulman, J.D.; Rizzo, W.B.; Snyder, R.D.; Murphy, J.V.; Kamoshita, S.; Migeon, C.J.; Moser, H.W. 1982: Adrenoleukodystrophy: effects of dietary restriction of very long chain fatty acids and of administration of carnitine and clofibrate on clinical status and plasma fatty acids Johns Hopkins Medical Journal 151(4): 164-172
Dierick, N.; Michiels, J.; Van Nevel, C. 2004: Effect of medium chain fatty acids and benzoic acid, as alternatives for antibiotics, on growth and some gut parameters in piglets Communications in Agricultural and Applied Biological Sciences 69(2): 187-190
Whitney, A.L.; Ryan, A.J. 1971: The effect of acetylsalicylic acid on free fatty acids in blood and possible relationship to aerobic performance Journal of Sports Medicine and Physical Fitness 11(2): 93-97
Holian, O.; Nelson, R. 1992: Action of long-chain fatty acids on protein kinase C activity: comparison of omega-6 and omega-3 fatty acids Anticancer Research 12(3): 975-980
Berde, C.B.; Kerner, J.A.; Johnson, J.D. 1980: Use of the conjugated polyene fatty acid, parinaric acid, in assaying fatty acids in serum or plasma Clinical Chemistry 26(8): 1173-1177
Datsenko, Z.M.; Krivenko, O.M.; Nechitaĭlo, L.O. 2001: Effect of "marine" phospholipids omega-3 fatty acids on the composition of fatty acids of rat liver microsomal membrane under oxidative stress Ukrains'kyi Biokhimichnyi Zhurnal 73(1): 60-64
Spieker-Polet, H.; Polet, H. 1981: Requirement of a combination of a saturated and an unsaturated free fatty acid and a fatty acid carrier protein for in vitro growth of lymphocytes Journal of Immunology 126(3): 949-954
Smith, S. 1981: Medium-chain fatty acyl-s-4'-phosphopantetheine-fatty acid synthase thioester hydrolase from lactating mammary gland of rat Methods in Enzymology 71 Pt C: 188-200
Molzer, B.; Kainz-Korschinsky, M.; Sundt-Heller, R.; Bernheimer, H. 1989: Phytanic acid and very long chain fatty acids in genetic peroxisomal disorders Journal of Clinical Chemistry and Clinical Biochemistry 27(5): 309-314
Singer, P. 1992: Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia Nutrition 8(2): 133-135
Hug, H.; Fiechter, A. 1973: Assimilation of aliphatic hydrocarbons by Candida tropicalis. II. Fatty acid profiles from cells grown on substrates of different chain length Archiv für Mikrobiologie 88(2): 87-96
Samur, Gülhan.; Topcu, A.; Turan, S. 2009: Trans fatty acids and fatty acid composition of mature breast milk in turkish women and their association with maternal diet's Lipids 44(5): 405-413
Kondo, E.; Kanai, K. 1981: Modification of the fatty acid pattern of phagocytic cell phospholipids and the course of tuberculous infection in mice fed with diets deficient in essential fatty acids Kekkaku: 56(9): 423-428
Garcia, J.; Ghisolfi, J.; Lapalu-Traon, C.; Periquet, B.; Olives, J.P.; Boyer, M.J.; Thouvenot, J.P. 1986: Screening of essential fatty acid deficiency in children. Respective value of the assay of fatty acids in total lipids and lipid fractions of the serum Annales de Biologie Clinique 44(4): 380-383
Zehaluk, C.M.; Walker, B.L. 1973: Effect of pyridoxine on red cell fatty acid composition in mature rats fed an essential fatty acid-deficient diet Journal of Nutrition 103(11): 1548-1553
Alling, C.; Bruce, A.; Karlsson, I.; Sapia, O.; Svennerholm, L. 1972: Effect of maternal essential fatty acid supply on fatty acid composition of brain, liver, muscle and serum in 21-day-old rats Journal of Nutrition 102(6): 773-782