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Requirement of a combination of a saturated and an unsaturated free fatty acid and a fatty acid carrier protein for in vitro growth of lymphocytes

Spieker-Polet, H.; Polet, H.

Journal of Immunology 126(3): 949-954

1981

ISSN/ISBN: 0022-1767
PMID: 7462639
Document Number: 171726
Two FFA served equally well. Palmitic and oleic acid could be replaced by other saturated and unsaturated FFA, respectively. The unsaturated FFA effectiveness was influenced by the chain length, the double bond number, and the double bond configuration. The double bond position appeared to have no effect. 125I-HSA binds to lymphocytes in a specific and nonspecific way. .beta.-L competes with 125I-HSA for the SA-binding sites. The specific binding and the growth supporting ability of SA have a similar dose response.

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