Plasma estimation of metronidazole by high performance liquid chromatography
Diquet, B.; Colin, J.N.; Singlas, E.
Annales de Biologie Clinique 38(4): 223-225
1980
ISSN/ISBN: 0003-3898 PMID: 7446875 Document Number: 159017
A rapid and sensitive analytic method for metronidazole (Flagyl) using high performance liquid chromatography is described. The use of a column filled with grafted silicium, lichrosorb RP 8, permits the direct injection of a plasma treated with perchloric acid and then centrifuged. The coefficients of capacity of metronidazole and of the internal standard solution were respectively 4.8 and 11.5. This technic permits one to carry out as a routine estimations of metronidazole, used in the treatment anaerobic gram negative septicemias.