Substitution of n-heptane for ethyl ether in USP assay for chlorpromazine hydrochloride in tablets, injections, and sirups
Kirchhoefer, R.D.; Myrick, J.W.
Journal - Association of Official Analytical Chemists 61(6): 1519-1520
1978
ISSN/ISBN: 0004-5756 PMID: 730658 Document Number: 134763
Peroxide levels above 0.0001% in the ethyl ether used in the USP XIX assay for chlorpromazine HCl, a powerful tranquilizer in humans, in tablets, syrups and injections produce a distorted spectrophotometric curve in the 350-220 nm region. The use of peroxide-free ethyl ether or n-heptane avoids this problem. Recoveries of 91-100% are obtained with either of these reagents.
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