Collaborative study of a colorimetric determination of benztropine mesylate in tablets and injections
Stricklin, M.C.
Journal - Association of Official Analytical Chemists 56(3): 681-683
1973
ISSN/ISBN: 0004-5756 PMID: 4779907 Document Number: 57785
A collaborative study was conducted on simulated tablet and injection preparations at 2 concentration levels each and a 20 tablet composite of a tablet simulating presently marketed dosage forms of benztropine mesylate. Analysis involves the extraction of benztropine from 0.2N H2SO4 with bromophenol blue in CHCl3. Absorbance of the dye complex formed is measured at about 410 nm. Average recoveries and standard deviations submitted were: 98.9±2.54 and 99.2±2.58, 100.1±2.78 and 100.0±2.19, and 100.1±2.23%, respectively. The method has been adopted as official first action.