Gas-liquid chromatographic quantitation of cocaine.HCl in pouders and tablets: collaborative study
Clark, C.C.
Journal - Association of Official Analytical Chemists 61(3): 683-686
1978
ISSN/ISBN: 0004-5756 PMID: 649560 Document Number: 130690
Eight laboratories collaboratively studied a method for the quantitative gas-liquid chromatographic (GLC) determination of cocaine. HC1 in solid forms. The cocaine.HQ and other water solubles are dissolved in dilute HC1. The aqueous solution is made weakly basic with K2HPO4, and the organic solubles are extracted into CHC13 for the GLC determination of cocaine. Tetracosane (n-C24) is incorporated in the extracting CHC13 as an internal standard. Five samples of known cocaine.HC1 concentration and one sample of commercial ground tablets were collaboratively studied. The cocaine. HC1 content ranged from 6 to 100%. Recoveries ranged from 98.7 to 103%; coefficients of variation ranged from 0.89 to 3.16. The method was adopted as official first action.