High pressure liquid chromatographic determination of oxazepam dosage forms: collaborative study
Bargo, E.S.
Journal - Association of Official Analytical Chemists 66(4): 864-866
1983
ISSN/ISBN: 0004-5756 PMID: 6885692 Document Number: 210958
A reverse phase high pressure liquid chromatographic method for the determination of oxazepam in tablets and capsules was collaboratively studied by 9 laboratories. Collaborators were supplied with 6 samples that included synthetic and commercial formulations. Tablet and capsule composites are diluted with methanol and filtered. Oxazepam is determined at 254 nm by using a C18 column. Mean recoveries of oxazepam from synthetic tablet and capsule formulations were 97.2 and 99.0%, respectively. Mean coefficients of variation for tablets and capsules ranged from 1.85 to 2.86%. The method has been adopted official 1st action.