High-pressure liquid chromatographic determination of benfurodil hemisuccinate in blood and urine
Turcant, A.; Patay, M.; Allain, P.
Journal of Chromatography 164(2): 195-203
1979
ISSN/ISBN: 0021-9673 PMID: 541410 Document Number: 153263
A sensitive and reliable method for quantitative determination of benfurodil hemisuccinate and benfurodil in plasma by high-pressure liquid chromatography on a Zorbax SIL column with a mean particle size of 7 micrometer and UV detection at 254 nm is described. Benfurodil hemisuccinate is stable in plasma but not in aqueous solutions. This is explained by its great fixation to plasma proteins which has been shown by equilibrium dialysis.