Properties of tetracycline hydrochloride tablets and their bioavailability
Zak, A.F.; Batuashvili, T.A.; Loseva, G.I.; Shatrova, V.M.; Ermolova, O.B.
Antibiotiki 25(3): 179-184
1980
ISSN/ISBN: 0003-5637 PMID: 7362222 Document Number: 157044
The properties of tetracycline hydrochloride tablets from various manufacturers were studied. Differences depending on the character of the coating were found: the film-coated tablets differed from dragee by a shorter period of the antibiotic transfer to solution, better disintegration, lower content of anhydroderivatives and higher stability. Correlation between the rate of tetracycline transfer to solution in vitro and the antibiotic absorption into blood on the oral use of the tablets was shown.