Antiarrhythmic activity of the hydrochloride of 1-methoxymethyl-2- (1-perhydroazepinyl) ethyl ester of 2- (n) -pentyloxycarbanilic acid
Gibala, P.; Sotníková, R.; Knezl, V.; Drímal, J.
Arzneimittel-Forschung 37(2): 149-152
1987
ISSN/ISBN: 0004-4172 PMID: 3580018 Document Number: 304025
Antiarrhythmic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid (BK 129) was studied in pentobarbital anesthetized dogs. The dose of 1 mg kg-1 i.v. suppressed ouabain-induced ventricular tachycardia for approx. 15 min. The minimal effective dosis was 0.72 +/- 0.09 mg kg-1 in comparison with 4.56 +/- 1.90 mg kg-1 of trimecaine and 6.80 +/- 0.86 mg kg-1 of quinidine. The doses of 1 and 2 mg kg-1 decreased ectopic activity 24-48 h after coronary artery ligation without complete suppression of extrasystoles. Epinephrine-induced arrhythmias were not prevented with the dose of 1 mg kg-1. The results demonstrate effectiveness of BK 129 in suppression of some types of arrhythmias.