Functional changes in compensatory hypertrophy of the canine kidney after uninephrectomy
Szöcs, E.; László, K.; Juszkó, J.; Bálint, P.
Acta Physiologica Academiae Scientiarum Hungaricae 51(1-2): 23-40
1978
ISSN/ISBN: 0001-6756 PMID: 754470 Document Number: 126384
Kidney weight and renal functional parameters were investigated in dogs 7 to 68 days after uninephrectomy. Average enlargement of the remaining kidney amounted to 35.1%. Renal blood flow (RBF) and glomerular filtration rate (GFR) calculated per 100 g actual kidney weight were identical in the non-hypertrophied controls and in the hypertrophied kidneys, i.e. structural and functional changes were strictly proportional. Calculation of mean nephron parameters (MNRBF and MNGFR) revealed an increase of about 43% in the hypertrophied kidneys, with an appropriate decrease in nephronal vascular resistance. The hypertrophied kidney showed an enhanced responsiveness to mannitol; increased MNRBF under stop flow conditions was due to a pronounced dilatation of the postglomerular vessels. There was no difference between control and hypertrophied kidneys in cortical zonal blood flow, as investigated by the labelled microsphere technique. Increase in parallel-connected cortical resistances towards the inner (juxtamedullary) zones was pronounced.