Enhancement of compensatory renal hypertrophy by beta-1-24 corticotropin in the rat
Reville, P.; Stephan, F.; de Laharpe, F.; Compagnie, M.J.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(5): 1122-1128
1977
ISSN/ISBN: 0037-9026 PMID: 203374 Document Number: 118423
In the rat, the administration of beta1-24-corticotrophin during 7 days following an uninephrectomy enhances significantly the compensatory hypertrophy of the remaining kidney. There is no increase in renal compensatory hypertrophy when ACTH is injected to previously adrenalectomized rats. This action of ACTH could be related to the diabetes mellitus induced by this hormone or to an increase in sodium reabsorption by the tubular epithelial cells.