Reception of aldosterone by the rat kidney in its compensatory hypertrophy
Akimov, I.A.; Azhipa, I.I.; Rodionov, A.A.
Problemy Endokrinologii 31(1): 74-76
1985
ISSN/ISBN: 0375-9660 PMID: 3157183 Document Number: 250521
A study was made of the effect of the compensatory hypertrophy of the rat kidney (on the 30th day) on the interaction of 3H-aldosterone with the receptors of the kidney cell tubules. It has been shown that the compensatory hypertrophy of the kidney is accompanied by an increased intensity of 3H-aldosterone binding with the receptors of the nephron cell cytoplasm and a decrease of the transfer of the hormonoreceptor cytoplasm and 3 receptor complex to the nucleus. These changes in the mechanism of aldosterone reception by the hypertrophic kidney can be accompanied by disturbed sensitivity of the organ to this mineralocorticoid.