Comparative affinity of several standard anti-secretory agents for the intestinal cholinergic receptors of of rats and dogs
Dureng, G.; Boero, C.; Baissat, J.; Labrid, C.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(4): 771-777
1977
ISSN/ISBN: 0037-9026 PMID: 22394 Document Number: 119601
Anticholinergic potentialities of four standard anti-secretory drugs (N-methyl-scopolammonium methylsulfate, atropine, diphemanil and prifinium) have been investigated with the help of molecular pharmacology techniques. The results gained with two different agonists (acetylcholine and carbachol) on rat and dog intestinal cholinergic receptors-jejunum and duodenum respectively-show : 1) That relative potentialities of the anticholinergic drugs (pA2) as well as those of the cholinomimetic agonists (pD2) are markedly modified according to which effector is used. 2) The N-methyl scopolammonium methylsulfate remains in any event the most potent anticholinergic drug investigated.