The effect of cholinergic-potentiating and cholinergic-blocking agents on reparative processes in the damaged gastric mucosa of rats
Losev, N.A.; Kuznetsova, N.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(5): 15-17
1992
ISSN/ISBN: 0869-2092 PMID: 1305444 Document Number: 402588
Rat experiments have indicated that increased lipid peroxidation in gastric tissue occurs with formation of cryogenic gastric ulcers. The use of methacin alone, 1 mg/kg i.p., and in combination with proserinum, 0.1 mg/kg, s.c., metamisyl alone, 1 mg/kg, i. p., and in combination with galanthamine hydrobromide, 1 mg/kg, s. c., result in acceleration of reparative process in the rat gastric walls and normalization of gastric tissue malonic dialdehyde levels. Methacin in combination with proserinum has been found to be most beneficial.