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On the capacity of presynaptic alpha receptors to modulate norepinephrine release from slices of rat neocortex and the affinity of some agonists and antagonists for these receptors

Wemer, J.; van der Lugt, J.C.; de Langen, C.D.; Mulder, A.H.

Journal of Pharmacology and Experimental Therapeutics 211(3): 445-451

1979

ISSN/ISBN: 0022-3565
PMID: 41934
Document Number: 148521
The capacity of presynaptic .alpha.-receptors on noradrenergic varicosities to modulate norepinephrine (NE) release in the rat neocortex was studied. Estimates of the affinity of 2 .alpha.-receptor agonists (NE and oxymetazoline) and 2 antagonists (phentolamine and yohimbine) for these receptors are presented. Cortex slices, previously labeled with -values of 8.0 and 7.4, respectively. From a comparison with previous data, presynaptic and postsynaptic .alpha.-receptors are apparently pharmacologically dissimilar.

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