Top Abstract Purchase Related
Home
>
Node
>
Subnode

Recombinant receptors for testing agonists and antagonists of VIP and PACAP receptors

Robberecht, P.; Gourlet, P.

Journal de Pharmacie de Belgique 51(3): 165-169

1996

ISSN/ISBN: 0047-2166
PMID: 8778350
Document Number: 467544
VIP and PACAP are structurally related neuropeptides. They interact with multiple classes of receptors that have been cloned recently. These receptors may be divided into two main classes: the PACAP type I receptors with a high affinity for PACAP and a low affinity for VIP and the PACAP type II receptors (with a high affinity for PACAP and VIP). Five different forms of the PACAP type I receptors are described and result from an alternative splicing of the messenger. Two distinct forms (VIP1 and VIP2 receptors) of the PACAP type II receptors are described. Considering this high number of variants and the coexistence of several variants in the same cell, the development of cell lines expressing a single type of receptor was required for the testing of selective agonists and antagonists. However, limits in the interpretation of the results obtained in the cell lines expressing the recombinant receptors were obvious: discovery of unusual receptor states and unusual coupling of cellular effectors when a high number of receptors was expressed.

Document emailed within 1 workday
Secure & encrypted payments

Wemer, J.; van der Lugt, J.C.; de Langen, C.D.; Mulder, A.H. 1979: On the capacity of presynaptic alpha receptors to modulate norepinephrine release from slices of rat neocortex and the affinity of some agonists and antagonists for these receptors Journal of Pharmacology and Experimental Therapeutics 211(3): 445-451
Ferry, R.C.; Unsworth, C.D.; Molinoff, P.B. 1993: Effects of agonists, partial agonists, and antagonists on the regulation of 5-hydroxytryptamine2 receptors in P11 cells Molecular Pharmacology 43(5): 726-733
Parkman, H.P.; Pagano, A.P.; Ryan, J.P. 1997: Dual effects of PACAP on guinea pig gallbladder muscle via PACAP-preferring and VIP/PACAP-preferring receptors American Journal of Physiology 272(6 Pt 1): G1433-G1438
Schreiber, R.; Brocco, M.; Audinot, V.; Gobert, A.; Veiga, S.; Millan, M.J. 1995: (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists Journal of Pharmacology and Experimental Therapeutics 273(1): 101-112
Luĭk, A.I.; Prokopenko, V.V.; Tanchuk, V.I.; Kholodovich, V.V.; Semeniuta, I.V. 1999: Common properties of pharmacological agonists and antagonists of surface membrane receptors Voprosy Meditsinskoi Khimii 45(6): 514-524
Geppetti, P.; Bertrand, C.; Bacci, E.; Huber, O.; Nadel, J.A. 1993: Characterization of tachykinin receptors in ferret trachea by peptide agonists and nonpeptide antagonists American Journal of Physiology 265(2 Pt 1): L164-L169
Grimm, U.; Moser, U.; Mutschler, E.; Lambrecht, G. 1994: Muscarinic receptors: focus on presynaptic mechanisms and recently developed novel agonists and antagonists Die Pharmazie 49(10): 711-726
Diaz, P.; Jones, D.G.; Kay, A.B. 1979: Histamine receptors on guinea-pig alveolar macrophages: chemical specificity and the effects of H1- and H2-receptor agonists and antagonists Clinical and Experimental Immunology 35(3): 462-469
Slepushkin, V.D.; Grössler, J.; Kuhne, H.; Scheuch, D.W. 1992: The effect of agonists and antagonists of opiate receptors on the activity of the kallikrein-kinin system in hemorrhagic shock Anesteziologiia i Reanimatologiia 3: 19-22
Priolo, E.; Libri, V.; Lopilato, R.; David, E.; Nappi, G.; Nisticò, G. 1991: Panic-like attack induced by microinfusion into the locus coeruleus of antagonists and inverse agonists at GABAA-receptors in rodents Functional Neurology 6(4): 393-403
Bełtowski, J.; Wójcicka, G.; Jamroz, A. 2003: Peroxisome proliferator-activated receptors (PPAR) in pathophysiology of the circulatory system and prospective use of agonists of these receptors in therapy Postepy Higieny i Medycyny Doswiadczalnej 57(2): 199-217
Sieghart, W.; Drexler, G.; Mayer, A.; Schuster, A. 1983: Interaction of benzodiazepine agonists and antagonists with different benzodiazepine receptors Advances in Biochemical Psychopharmacology 38: 11-19
Holzgrabe, U.; Nachtsheim, C.; Siener, T.; Drosihn, S.; Brandt, W. 1997: Opioid agonists and antagonists, opioid receptors Die Pharmazie 52(1): 4-22
Niewiadomski, P.ł; Nowak, J.Z.; Sedkowska, P.; Zawilska, J.B. 2002: Rapid desensitization of receptors for pituitary adenylate cyclase-activating polypeptide (PACAP) in chick cerebral cortex Polish Journal of Pharmacology 54(6): 717-721
Kalra, S. 2013: Glucagon-like peptide-1 receptors agonists (GLP1 RA) Jpma. Journal of the Pakistan Medical Association 63(10): 1312-1315
Briel, D.; Rybak, A.; Kronbach, C.; Unverferth, K. 2008: Thieno[2,3-d]pyrimidines as antagonists of the glutamate receptors Die Pharmazie 63(11): 823-826
Aranda, P.; Aranda F, J. 2000: Renal protection with antagonists of the angiotensin Ii receptors Medicina Clinica 114(Suppl 1): 29-33
Hulme, E.C.; Birdsall, N.J.; Burgen, A.S.; Mehta, P. 1978: The binding of antagonists to brain muscarinic receptors Molecular Pharmacology 14(5): 737-750
Manzoni, O.; Prezeau, L.; Rassendren, F.A.; Sladeczek, F.; Curry, K.; Bockaert, J. 1992: Both enantiomers of 1-aminocyclopentyl-1,3-dicarboxylate are full agonists of metabotropic glutamate receptors coupled to phospholipase C Molecular Pharmacology 42(2): 322-327
Niewiarowski, S.; McLane, M.A.; Kloczewiak, M.; Stewart, G.J. 1994: Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors Seminars in Hematology 31(4): 289-300