Thieno[2,3-d]pyrimidines as antagonists of the glutamate receptors
Briel, D.; Rybak, A.; Kronbach, C.; Unverferth, K.
Die Pharmazie 63(11): 823-826
2008
ISSN/ISBN: 0031-7144 PMID: 19069244 Document Number: 622540
Although the function of the kainate receptors in the brain is still not clear, they are increasingly defined as targets in the development of new classes of anti-epileptics. The thienopyrimidines described in this report were tested for their antagonistic effect at the kainate receptor subtypes GluR5 and GluR6. The highest effectiveness was obtained by a 4-ethoxy-thieno[2,3-d]pyrimidin with an IC50 = 68 microM at the GluR6 receptor.
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