The influence of the cellular composition of primary tumour cell suspensions on the in-vitro cultural growth rate with monolayer cultivation--a contribution to tumor-immunological interrelationships
Schönfelder, M.
Archiv für Geschwulstforschung 45(8): 810-813
1975
ISSN/ISBN: 0003-911X PMID: 1230126 Document Number: 94878
Quantitative differential analyses were performed on smears of primary suspensions of human malignant tumours prepared by tryptic digestion. We correlated the findings thus obtained with the in-vitro rate of positive cultivation in monolayer cultivation and clinical courses of tumour carriers. This way we found, that the ratio of lymphocytes to tumour cells in the cell suspension has significant influence on the in-vitro growth rate. We have explained the mutual reaction between lymphocytes and tumour cells as expression of a specific immunological reaction. The correlation with the clinical courses of tumour carriers underlines the in-vitro findings.