Use of regression analysis in the quantitative evaluation of the activity of biological preparations
Kheĭfets, L.B.; Feofanova, T.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 8: 96-102
1975
ISSN/ISBN: 0372-9311 PMID: 1202888 Document Number: 89133
Use of regression analysis in the assessment of the activity of biological preparations under experimental conditions permitted not only to assess the quantitative effect (ED50) more strictly, but also to find other parameters of importance for the results of comparison, for example with the standard, i.e. in standardization. To these belong regression coefficient, parallelism of regressions, and the relative potency. By the presence of a parallelism one can judge the similarity between the activity mechanism of the active principle of the preparations being compared. Relative potency characterizes the activity of the preparation in the relative values in comparison with the standard, with a statistical evaluation of this value with the aid of the confidence interval. The authors suggest a program for Mir-2 computer facilitating the calculations in using the analystical method which is more objective than the graphic method of assessment of the linear dosage-response curve.