Pyrimidinyl nicotinic acid and cerebrocortical necrosis
Lilja, C.G.
Acta Veterinaria Scandinavica 16(1): 24-30
1975
ISSN/ISBN: 0044-605X PMID: 1136907 Document Number: 85778
Pyrimidinyl nicotinic acid (PNA) exhibits great structural similarities to amprolium, which is a known thiamine antagonist. Experimental cerebrocortical necrosis (CCN) has been induced by oral administration of amprolium. PNA has been demonstrated in ruminal fluid from animals with CCN. The aim of this investigation was to study whether PNA can act as thiamine antagonist and whether it can give rise to CCN. For this purpose PNA was synthesized and was daily given i/v to a calf. The dose corresponded to roughly 10 times the content of thiamine in the blood. After three weeks the dose was doubled. During the 9-week experiment no clinical sign of thiamine deficiency or CCN was noticeable. The values for all recorded blood chemical values, with the exception of occasional GOT and pyruvate kinase values, were within the normal limits of variation. Rats were used in a similar experiment; PNA was homogeneously added to their feed in quantities equivalent to five and 10 times the thiamine content; the rats were clinically healthy throughout the 8-week experiment; no significant influence on transketolase activity or thiamine pyrophosphate effect was observed.