Antithrombotic action of nicotinic acid
Baluda, V.P.; Eristavi, Z.A.; Sushkevich, G.N.
Kardiologiia 14(11): 105-107
1974
ISSN/ISBN: 0022-9040 PMID: 4139303 Document Number: 70810
Wistar rats weighing 150 to 180 g were left intact or, to induce blood hypercoagulation, were given intraperitoneal injections of hydrocortisone 5 mg/kg or pituitrin 0.05 unit. After 15 min the rats were given nicotinic acid intravenously and blood was sampled from the jugular vein after another 15 min. In another experiment intravascular clotting was induced by intraperitoneal injection of pituitrin and, 15 min later, thromboplastin; after another 15 min nicotinic acid 1 mg/kg was given. The rats were killed after 30 min and examined for signs of vascular clotting. In control rats nicotinic acid reduced fibrinase (factor XIII) activity by 27%, tolerance of fibrin clot to plasmin by 23% and adhesion of blood platelets to foreign surfaces. Hydrocortisone and pituitrin increased factor XIII activity by 36 and 37%, respectively, and tolerance of fibrin clot to plasmin by 50 and 35%; they also stimulated adhesive ability of platelets, indicating that they contribute towards the tendency of the blood to clot intravascularly. Nicotinic acid almost totally prevented intravascular clotting induced by thromboplastin and pituitrin, showing that it has a thrombolytic effect.