Nicotinic acid and restraint induced ulcers
Lindenbaum, E.S.; Diamond, B.; Yaryura-Tobías, J.A.
Acta Physiologica Latino Americana 23(4): 288-292
1973
ISSN/ISBN: 0001-6764 PMID: 4797631 Document Number: 67152
Rats stressed by physical restraint and by deprivation of food and water to produce gastric ulcers were given chlorpromazine or nicotinic acid. Doses of nicotinic acid 16.6, 33.2 and 62.5 mg/kg reduced stress, whereas the two smaller doses of chlorpromazine were ineffective in preventing stress-induced ulcer.
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