Cerebrocortical necrosis in ruminants: effect of thiaminase type 1-producing Clostridium sporogenes in lambs
Cushnie, G.H.; Richardson, A.J.; Lawson, W.J.; Sharman, G.A.
Veterinary Record 105(21): 480-482
1979
ISSN/ISBN: 0042-4900 PMID: 538876 Document Number: 152071
Large numbers of orally inoculated thiaminase type 1-producing C. sporogenes failed to become established in the alimentary tract of two conventionally born lambs. Conversely, when similar inoculations were given to two gnotobiotic lambs, large populations were established in the rumen, and correspondingly high levels of thiaminase were produced. No clinical symptoms of thiamine deficiency or cerebrocortical necrosis were seen despite the presence of high levels of thiaminase in the rumen of one of the gnotobiotic lambs for 86 days.