Transport of 2,5-dimethoxy-4-methylamphetamine by macroheterocycles across erythrocyte membranes
Karaseva, T.L.; Iavorskiĭ, A.S.; Pavlovskiĭ, V.I.; Tsapenko, Z.N.
Ukrainskii Biokhimicheskii Zhurnal 65(5): 95-98
1993
ISSN/ISBN: 0201-8470 PMID: 8160305 Document Number: 7962
Transport of 2,5-dimethoxy-4-methylamphetamine across human erythrocytes by the 18-crown-6, monoaza-15-crown-5 and diaza-18-crown-6 is studied and evaluated spectrophotometrically. It is shown that crown-ethers at low concentration (1-2 mM) protect erythrocytes against their natural homolysis. 2,5-dimethoxy-4-methylamphetamine provides 2-5% hemolysis of erythrocytes. In the presence of macrocycles (5 mM) hemolysis of erythrocytes increases from 6.5 to 30%. A hemolytic effect of 2,5-dimethoxy-4-methylamphetamine depends on the structure of the crown ethers and, apparently, confirms significant role of complexes of the crown-ethers with amine in these processes.
Document emailed within 1 workday
