Cardiovascular and gross behavioral effects of amphetamine, 2-amino-1- (2,5-dimethoxy-4-methylphenyl) propane (DOM) and 2-amino-1- (2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) in the conscious dog
Buyniski, J.P.; Smith, M.L.; Bierwagen, M.E.
Research Communications in Chemical Pathology and Pharmacology 8(2): 213-221
1974
ISSN/ISBN: 0034-5164 PMID: 4859236 Document Number: 5060
Intravenous administration of increasing doses of amphetamine (0.1 3 mg/kg), DOM (0.1 - 1 mg/kg) and BL-3912A (0.1 - 5 mg/kg) to conscious beagle dogs resulted in appreciable gross behavioral and cardiovascular changes. Gross behavioral changes ranged from stereotyped activity and disorientation with amphetamine to catatonia with DOM and brief central nervous system stimulation with BL-3912A. In conscious dogs, all three drugs raised mean aortic blood pressure, with amphetamine being the most effective (62 mm Hg) followed by DOM (48 mmHg) and BL-3912A (41 mmHg). Heart rate was consistently reduced only by amphetamine. BL-3912A resulted in depressor responses on blood pressure in anesthetized dogs and this suggests that in the conscious dog BL-3912A may be activating centers in the central nervous system to effect a pressor response. The elevation of blood pressure in the conscious dog induced by amphetamine and DOM is mediated, at least partly, via their peripheral actions.
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