Behavioral changes induced by 2,5-dimethoxy 4-methyl-amphetamine (DOM, STP) in primate dyads
Tyler, C.B.; Schlemmer, R.F.; Narasimhachari, N.; Davis, J.M.
Communications in Psychopharmacology 2(4): 337-342
1978
ISSN/ISBN: 0145-5699 PMID: 103677 Document Number: 3633
The behavioral effects induced by 2,5-dimethoxy 4-methylamphetamine (DOM), a hallucinogen, were studied in four, adult Stumptail macaque females housed as two pairs. Following a baseline observation period, DOM, 0.17 mg (base)/kg, was administered intramuscularly once daily for five consecutive days to one member of each pair. At the end of one week, there was a cross-over and the previously untreated monkeys received similar DOM treatment for five days. Upon acute administration, DOM induced decreases in the total initiated social activity, social grooming, self-grooming, and submissive gestures in treated monkeys. At the same time, DOM induced abnormal behavior including involuntary limb jerks, dog-like "wet shakes," hypervigilance, and ptosis. During chronic administration, partial tolerance developed to DOM-induced limb jerks, wet shakes, and ptosis, but not to hypervigilance. The results of this study suggest that this paradigm may provide an excellent model system for the study of the psychopharmacology of DOM and other hallucinogens.
Document emailed within 1 workday
