Influence of cholestasis on enzymatic induction with phenobarbital and other enzymatic aspects: experimental studies on guinea pigs
Di Simone, A.; Catanzano, C.; Riegler, G.; Rinaldi, M.; Di Cesare, D.; Gentile, S.; Gaeta, L.; Coltorti, M.
Quaderni Sclavo di Diagnostica Clinica E di Laboratorio 10(4): 481-490
1974
ISSN/ISBN: 0033-4979 PMID: 4156599 Document Number: 70968
Investigations in guinea pigs to evaluate interferences between cholestasis and enzymatic induction by phenobarbital, and influences that both experimental conditions exert on the levels of gamma-glutamyl transpeptidase in microsomes and other subcellular fractions, have shown that: 1) cholestasis inhibits inductions of cytochrome P-450 from phenobarbital; 2) gamma-glutamyl transpeptidase is not an inducible enzyme in guinea pig; 3) rises or ferum gamma-glutanyl transpeptidase produced either by cholestasis or phenobarbital administration, are not related to an increased enzymatic synthesis in the various subcellular fractions of liver cell.