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Experimental studies of Bordetella bronchiseptica infection in guinea pigs

Krüger, M.; Eliés, B.

Archiv für Experimentelle Veterinarmedizin 38(5): 658-663

1984

ISSN/ISBN: 0003-9055
PMID: 6529325
Document Number: 232458
Two B. bronchiseptica strains, one of guinea pig origin and one international reference strain (22067), caused acute infection in guinea pigs inoculated intranasally or intraperitoneally, and spread to in-contact guinea pigs, though a relatively high dose was required to produce a lethal infection. The guinea pig strain was re-isolated from all surviving guinea pigs that had been inoculated intranasally. Diagnostic serological titres appeared only in animals given an intranasal inoculum in the LD50 range. A merthiolate-inactivated vaccine prepared with the guinea pig strain and containing imcomplete Freund's adjuvant protected 59% of guinea pigs against intranasal challenge with an inoculum exceeding the LD50.

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