Changes induced with cyclophosphamide in the lympho-reticular elements with specific enzymatic activities of the splenic white pulp in rats and guinea-pigs
Catayee, G.; Senelar, R.; Chalet, M.; Kochoyan, Y.
Bulletin de l'Association des Anatomistes 59(165): 377-382
1975
ISSN/ISBN: 0376-6160 PMID: 1203550 Document Number: 85183
The effect of cyclophosphamide, one potent immunosupressor drug, was used to differenciate the behaviour of two types of Reticular cells, the phosphatasic acid and the 5'nucleotidasic cells. The first exhibit macrophagic and migratory properties, the second are devoid of these criteria but remain associated with the presence of T-lymphocytes. This suggests its possible role in the nutrition and the differential evolution of T-lymphocytes.