Top Abstract Purchase Related
Home
>
Node
>
Subnode

Evaluation of antiviral activity of plant extracts against foot and mouth disease virus in vitro

Younus, I.; Siddiq, A.; Ishaq, H.; Anwer, L.; Badar, S.; Ashraf, M.

Pakistan Journal of Pharmaceutical Sciences 29(4): 1263-1268

2016

ISSN/ISBN: 1011-601X
PMID: 27393440
Document Number: 685931
The aim of this study was to evaluate antiviral activity of chloroformic leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Antiviral and cytotoxic activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. The concentrations which resulted in cell survival percentages of greater than 50% are considered to be effective antiviral concentrations. From the tested plant extracts, Moringa oleifera showed potent antiviral activity (p<0.05) while Azadirachta indica showed significant antiviral activity in the range of 1-50μ/ml & 12-100μ/ml respectively. In contrast no antiviral activity was observed by Morus alba as all the tested concentration resulted in significant reduction (p<0.05) in cell survival percentage.

Document emailed within 1 workday
Secure & encrypted payments

Petr, G.; Láznicka, F. 1971: Influence of temperature on complement fixation activity of the foot-and-mouth disease virus Veterinarni Medicina 16(11): 689-696
Girard, H.C. 1976: Several criteria of evaluation of foot-and-mouth disease virus reproduced in cell cultures in suspension Developments in Biological Standardization 35: 91-96
Palma, E.L. 1975: Foot and mouth disease virus Revista de la Asociacion Argentina de Microbiologia 7(3): 111-124
Zheng, Y.M.; Chang, Z.R.; Jiang, L.L.; Ji, H.; Chen, G.P.; Luo, P.; Pan, J.J.; Tian, X.L.; Wei, L.L.; Huo, D.; Miao, Z.P.; Zou, X.N.; Chen, J.H.; Liao, Q.H. 2017: Severe cases with hand, foot and mouth disease: data based on national pilot hand, foot and mouth disease surveillance system Zhonghua Liu Xing Bing Xue Za Zhi 38(6): 759-762
Rai, M.K. 1996: In vitro evaluation of medicinal plant extracts against Pestalotiopsis mangiferae Hindustan Antibiotics Bulletin 38(1-4): 53-56
Pereira, H.G. 1976: Subtyping of foot-and-mouth disease virus Developments in Biological Standardization 35: 167-174
Shibnev, V.A.; Garaev, T.M.; Finogenova, M.P.; Kalnina, L.B.; Nosik, D.N. 2015: Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus Voprosy Virusologii 60(2): 35-38
Meyer, L.; Heinrich, H.W.; Weber, S. 1987: CDNA cloning of foot-and-mouth disease virus Archiv für Experimentelle Veterinarmedizin 41(5): 665-670
Toshkova, R.; Nikolova, N.; Ivanova, E.; Ivancheva, S.; Serkedjieva, J. 2004: In vitro investigation on the effect of a plant preparation with antiviral activity on the functions of mice phagocyte cells Die Pharmazie 59(2): 150-154
Liebermann, H.; Kwasniowski, W.; Wazel, W.; Holl, H. 1987: Preparation of the 35S ribonucleic acid of foot-and-mouth disease virus Archiv für Experimentelle Veterinarmedizin 41(5): 671-676
Sobko, A.I.; Sokolov, L.N.; Gritsenko, A.I.; Nesterova, I.F.; Prokhorov, V.N.; Tcherniaev, I.A.; Rodionov, V.I. 1972: Identification of epizootic strains of foot-and-mouth disease virus in the U.S.S.R Bulletin - Office International des Epizooties 77(5): 913-927
Tekerlekov, P.; Popov, G.; Vasileva, L.; Nikolova, E. 1985: Experiments to purify and concentrate the foot-and-mouth disease virus Veterinarno-Meditsinski Nauki 22(10): 3-9
Tewari, S.C.; Singh, I.P.; Sharma, V.K.; Prasad, S. 1976: Susceptibility of the Indian squirrel to foot-and-mouth disease virus Veterinary Record 99(4): 71-72
Della Loggia, R.; Tubaro, A.; Redaelli, C. 1981: Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them Rivista di Neurologia 51(5): 297-310
Traub, E.; Moehlmann, H. 1946: Studies on immunological variants of types A and B of the foot and mouth disease virus Berliner und Münchener Tierärztliche Wochenschrift 12(1): 1-5
Liebermann, H.T.; Meissner, J.; Schulze, P.; Thalmann, G. 1976: Various physical and chemical properties of the 73s unit of the foot-and-mouth disease virus Archiv für Experimentelle Veterinarmedizin 30(6): 813-821
Bauer, K.; Müller, H.; Eissner, G. 1977: Epidemiologic significance of permanent foot-and-mouth disease virus excretors Berliner und Munchener Tierarztliche Wochenschrift 90(1): 1-5
Augé de Mello, P.; Honigman, M.N.; Fernandes, M.V.; Gomes, I. 1970: Further information on the survival of modified foot-and-mouth disease virus in cattle Bulletin - Office International des Epizooties 73(5): 489-505
Parker, J. 1971: Presence and inactivation of foot-and-mouth disease virus in animal faeces Veterinary Record 88(25): 659-662
Razdan, R.; Sen, A.K.; Rao, B.V.; Suryanarayana, V.V. 1996: Stability of foot-and-mouth disease virus, its genome and proteins at 37 degrees C Acta Virologica 40(1): 9-14