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Calcium-depended mechanism of the antiplatelet activity of benzimidazole derivative RU-891

Spasov, A.A.; Kucheriavenko, A.F.; Anisimova, V.A.

Eksperimental'naia i Klinicheskaia Farmakologiia 77(3): 16-19

2014

ISSN/ISBN: 0869-2092
PMID: 24800520
Document Number: 674737
We have studied the effect of the new benzimidazole derivative RU-891, known to exhibit antiaggregant activity in vitro and in vivo, on the level of intracellular calcium ions in platelets of laboratory rabbits. Compound RU-891 was found to inhibit the thrombin-induced growth of intracellular calcium ion level in thrombocytes.This effect exceeded t he action o f reference d rugs and was not connected w ith the influence of RU-891 o n the potential-dependent c alci u m channels.

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