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Role of calcium on protein phosphorylation in collagen-stimulated platelets. Effect of a new dihydropyridine derivative

Catalán, R.E.; Martínez, A.M.; Aragonés, M.D.; Encabo, P.; Hernández, F.

Biochemistry International 19(4): 919-928

1989

ISSN/ISBN: 0158-5231
PMID: 2619757
Document Number: 345891
We investigated the effect of extracellular calcium on protein phosphorylation stimulated by collagen in rabbit platelets. We found that collagen-induced increase in 40 kDa protein phosphorylation was maximum at 2 mM Ca2+, and was evident in buffer with zero Ca2+ but not in the presence of EGTA. We also studied the effects of a new dihydropyridine derivative, which has antithrombotic properties, on protein phosphorylation induced by collagen. This compound inhibited the phosphorylation of 40 kDa and 20 kDa protein independently of the extra-cellular Ca2+. The inhibitory effect was dose-dependent but not time-dependent and was more evident when the drug was added before or simultaneously with collagen.

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