The role of prostaglandins in the effect of beta-blockers on stimulated blood platelets
Nosál', R.; Jancinová, V.; Petríková, M.
Vnitrni Lekarstvi 37(3): 261-267
1991
ISSN/ISBN: 0042-773X PMID: 1674390 Document Number: 376331
Atenolol, a selective beta-blocker, slightly potentiates the stimulated aggregation of platelets against dose-dependence. The drug potentiates similarly stimulated release of arachidonic acid, it does not influence the formation of malondialdehyde and the thromboxane B2 production in stimulated platelets. The non-selective beta-blocker propranolol inhibits in a dose-dependent way stimulated aggregation, the release of arachidonic acid, it reduces thromboxane B2 production in stimulated platelets. The authors revealed that the anti-aggregating action of beta-blockers is closely related to their ability to influence prostaglandin synthesis in stimulated platelets.