Top Abstract Purchase Related
Home
>
Node
>
Subnode

Morphological changes in brain tissues of rat with local permanent ischemia model under the action of 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate

Bagdasarian, N.A.; Khostikian, N.G.; Alikhanian, K.B.; Meliksetian, V.S.; Bagdasarian, M.G.; Stepanian, A.G.; Kukhtarova, A.M.; Mirzoian, N.R.

Eksperimental'naia i Klinicheskaia Farmakologiia 77(12): 10-13

2014

ISSN/ISBN: 0869-2092
PMID: 25739186
Document Number: 674361
The influence of 2-methyl-6-ethyl-3-hydroxypiridine hemisuccinate on the morphological state of rat brain tissue after the occlusion of left middle cerebral artery has been studied. It was found that 6- and 12-day treatment with 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate at a dose of 100 mg/kg (intraperitoneal) led to regenerative processes in ischemic brain tissue. The latter treatment duration was most effective.

Document emailed within 1 workday
Secure & encrypted payments

Gan'shina, T.S.; Gorbunov, A.A.; Gnezdilova, A.V.; Kurdiumov, I.N.; Avdiunina, N.I.; Piatin, B.M.; Mirzoian, R.S. 2011: Influence of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate on cerebral blood perfusion in rats under experimental pathology conditions Eksperimental'naia i Klinicheskaia Farmakologiia 74(8): 17-22
Nalini, G.; Namasivayam, A. 1992: Influence of ethyl and methyl alcohol on rat brain histamine content Indian Journal of Physiology and Pharmacology 36(4): 285-286
Güthert, H.; Warzok, R. 1974: On the carcinogenic action of methyl- and ethyl-nitrosourea in rats after transplacental and postnatal application Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 118(2-3): 115-123
Chaudiere, J.; Clement, M.; Gerard, D.; Bourre, J.M. 1988: Brain alterations induced by vitamin e deficiency and intoxication with methyl ethyl ketone peroxide Neurotoxicology 9(2): 173-179
Korostovtseva, N.V.; Volkova, Z.A.; Baev, V.I.; Brattseva, S.A. 1975: Characteristics of glycolysis in the tissues of the brain and myocardium of rats in acute ischemia of the brain Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 63-67
Chesnokova, N.B.; Kost, O.A.; Nikol'skaia, I.I.; Beznos, O.V.; Binevskiĭ, P.V.; Makarov, P.V.; Stoliarova, E.P.; Pavlenko, T.A. 2008: Experimental rationale for local use of angiotensin-converting enzyme inhibitors for the treatment of ocular tissue ischemia on a model of postburn conjunctival ischemia Vestnik Oftalmologii 124(4): 28-31
Jović, R.; Bosković, B. 1970: Antidotal action of pyridinium oximes in poisoning by O,O-diethyl-S-(2-(N-methyl-N-phenylamino)ethyl) thiophosphonate methylsulfomethylate (GT-45) and its two new analogs Toxicology and Applied Pharmacology 16(1): 194-200
Zhirkova, I.V.; Stepanenko, S.M.; Kucherov, I.I. 2011: Postoperative analgesia of newborns using local anesthetic administered through wound irrigation catheter of permanent action Anesteziologiia i Reanimatologiia 1: 55-58
Toyo-oka, T.; Kamishiro, T.; Gotoh, Y.; Fumino, H.; Masaki, T.; Hosoda, S. 1986: Temporary salvage of ischemic myocardium by the protease inhibitor bis[ethyl(2R,3R)-3-[(S)-methyl-1-[4-(2,3,4-trimethoxyphenyl-methyl) piperazin-1-ylcarbonyl]butyl-carbonyl]oxiran-2-carbo xylate]sulfate Arzneimittel-Forschung 36(4): 671-675
Wilms, K.; Wilmanns, W. 1973: Permanent lymphoblastic cell cultures as model for study of action mechanism of antileukemic substances Verhandlungen der Deutschen Gesellschaft für Innere Medizin 79: 1379-1381
Korzhevskiĭ, D.E.; Lentsman, M.V.; Kirik, O.V.; Otellin, V.A. 2012: Morphological types of activated microglia in the hippocampus observed following transient total brain ischemia Morfologiia 142(5): 30-33
Kasavina, B.S.; Maĭchuk, I.F.; Dalgat, L.D.; Romashchenko, A.D. 1982: Effect of the water-soluble antioxidant hydroxypyridine-6 on the intensity of lipid peroxidation in eye tissues in experimental ophthalmic herpes Biulleten' Eksperimental'noi Biologii i Meditsiny 94(7): 27-28
Karwowski, B.; Jura, E.; Krasicka, J.; Kruszewska, J.; Laskowska-Studniarska, W.; Szymchel, J.; Nielubowiczowa, H. 1982: Evaluation of sulocton action in patients with atherosclerotic brain ischemia Neurologia i Neurochirurgia Polska 16(4): 237-243
Hubs'kyĭ, I.I.; Bielenichev, I.F.; Kovalenko, S.I.; Goriushko, H.H.; Bukhtiiarova, N.V.; Litvinova, N.V.; Nikitin, V.S.; Pavlov, S.V.; Babenko, L.P. 2012: Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia Ukrains'kyi Biokhimichnyi Zhurnal 84(5): 89-96
Khodakivs'kyĭ, O.A. 2013: Characteristics of antiischemic and nootropic properties of ademol in a rat model of acute brain ischemia Fiziolohichnyi Zhurnal 59(5): 71-77
Capo, I.; Lalosević, D. 2011: Interpretation of dark neurons in experimental model of ischemia, neurointoxication and brain infection Medicinski Pregled 64(1-2): 101-106
Tang, W.X. 1989: Pathologic attributes and pathogenesis of brain edema in a rat model of cerebral ischemia with reperfusion Zhonghua Yi Xue Za Zhi 69(3): 160-162
Buşilă, V.T.; Mârza, A.; Dragomirescu, M.; Marţincu, V.; Stănescu-Lupu, D.; Novac, E. 1970: Comparative action of hydrocortisone hemisuccinate and epsilon-aminocaproic acid in experimental endotoxic shock Medicina Interna 22(3): 361-370
Kuga, T.; Naito, J. 1974: Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolinone hydrochloride (doxapram). 2. Peripheral action Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 70(2): 165-174
Grishina, T.R.; Gromova, O.A.; Sadin, A.V.; Nazarenko, O.A.; Zhidomorov, N.I.; Borzunov, M.P.; Vatsuro, A.A.; Nikonov, A.A. 2004: The influence of betaserk and cinarizine on vestibular function, highest nervous activity and brain circulation in chronic cerebral ischemia: a model study Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 104(2): 61-63