Characteristics of antiischemic and nootropic properties of ademol in a rat model of acute brain ischemia
Khodakivs'kyĭ, O.A.
Fiziolohichnyi Zhurnal 59(5): 71-77
2013
ISSN/ISBN: 2522-9028 PMID: 24400568 Document Number: 670454
In experiments with the rat model of acute disorder of encephalic circulation (bilateral carotid occlusion) it was found that introduction of derivate of adamantan 1-adamantiloxy-3-morfolino-2 propanol (under conventional name ademol) in the dose 2 mg/kg intraabdominal in treatment regimen (in an hour after reconstruction of insult and further 1 time every 24 hours during 21 days) was accompanied by a recovery of mnemotropic properties and is more effective than cytikolin, resulting in a decreased lethality and neurological deficiency in acute and recovery periods of insults. The data received proved the usefulness of development of ademol based cerebroprotective remedy.