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Influence of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate on cerebral blood perfusion in rats under experimental pathology conditions

Gan'shina, T.S.; Gorbunov, A.A.; Gnezdilova, A.V.; Kurdiumov, I.N.; Avdiunina, N.I.; Piatin, B.M.; Mirzoian, R.S.

Eksperimental'naia i Klinicheskaia Farmakologiia 74(8): 17-22

2011

ISSN/ISBN: 0869-2092
PMID: 22232909
Document Number: 650624
Experiments on rats showed that 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate increases cerebral blood flow in the system of carotid arteries both in intact animals and under conditions of global transient ischemia. In combination with tropoxin, 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate enhances the blood flow in the inner carotid artery of intact rats and the local blood flow under conditions of global transient ischemia. A combination of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate and tropoxin increases baseline cerebral blood flow and decreases the constrictor reaction of cerebral blood vessels to 5HT(2B/2C) receptor agonist meta-chlorophenylpiperazine.

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