Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia
Hubs'kyĭ, I.I.; Bielenichev, I.F.; Kovalenko, S.I.; Goriushko, H.H.; Bukhtiiarova, N.V.; Litvinova, N.V.; Nikitin, V.S.; Pavlov, S.V.; Babenko, L.P.
Ukrains'kyi Biokhimichnyi Zhurnal 84(5): 89-96
2012
ISSN/ISBN: 0372-3909 PMID: 23342639 Document Number: 659263
Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative--compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPO-antioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional status of brain cells are improved under administration of the compound NC-224. Administration of the compound NC-224 to rats promoted a decrease of the lethality index and signs of neurological deficiency.