The action of acute alcoholic intoxication on the antioxidant system and creatine kinase activity in the brain of rat embryos
Burmistrov, S.O.; Mashek, O.P.; Kotin, A.M.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(5): 54-56
1992
ISSN/ISBN: 0869-2092 PMID: 1305455 Document Number: 404511
The activity of superoxide dismutase (SOD) was enhanced in the brain of 14-day rat embryos 1 and 3 hours after single administration of ethanol to pregnant rats. Concurrently, the levels of lipid peroxidation were changing in these periods. Ethanol, 1 g/kg, increased LPO levels in the 14-day embryonic brain, whereas its dose of 3 g/kg decreased them. It is concluded that with single administration of ethanol, free-radical processes are activated in the embryonic brain. It is suggested that the activity of creatine kinase decreases concurrently with an increase in SOD activity due to the damaging action of superoxide radicals on the enzyme molecule.