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Effect of cinnarizine on the brain mitochondrial oxidative system, antioxidant blood activity, and the rat behavior in hypoxia

Belostotskaia, L.I.; Chaĭka, L.A.; Gomon, O.N.

Eksperimental'naia i Klinicheskaia Farmakologiia 66(6): 16-19

2003

ISSN/ISBN: 0869-2092
PMID: 14743704
Document Number: 564476
The effect of cinnarizine on the functional state of brain mitochondria, the activity of blood antioxidant system, and the behavior of rats was studied under model hypoxic hypoxia conditions. A four-day treatments with cinnarizine (50 mg/kg, twice per day via a gastric tube) prevents the hypoxic brain edema development, restores NAD+ dependent oxidation of a succinate substrate, normalizes emotional-exploratory activity, and causes hyperlocomotion of the experimental animals, while not influencing a high level of activity of the blood antioxidant system.

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