Clinical studies of panipenem/betamipron in pediatrics
Morita, H.; Hamada, F.; Fujieda, M.; Hosokawa, T.; Maeda, A.; Maeda, H.; Hashizume, M.; Kido, S.; Hisakawa, H.; Kawakubo, K.
Japanese Journal of Antibiotics 45(4): 437-442
1992
ISSN/ISBN: 0368-2781 PMID: 1518127 Document Number: 404512
We conducted clinical studies on panipenem/betamipron (PAPM/BP), a newly developed parenteral carbapenem antibiotic, for its clinical application in the field of pediatrics. 1. A clinical study was performed on 13 children with infections, including 6 with acute bronchopneumonia, 1 each with acute pharyngitis, acute bronchitis, sepsis, staphylococcal scalded skin syndrome, urinary tract infection, subcutaneous abscess and furuncle. PAPM/BP was administered by intravenous drip infusion. Doses varied from 12 to 27 mg/kg body weight were given t.i.d. or q.i.d. Lengths of treatment ranged from 4 to 25 days. Clinical efficacies were excellent in 3 and good in 9 cases, with an efficacy rate of 92%. 2. No adverse reactions were observed. In laboratory tests, elevations of GOT, GPT and urobilinogen were observed in 3 cases. It was concluded that PAPM/BP was a promising drug for the treatment of bacterial infections in children.