Clinical studies on norfloxacin in the field of pediatrics
Haruta, T.; Kuroki, S.; Okura, K.; Kobayashi, Y.
Japanese Journal of Antibiotics 43(5): 872-876
1990
ISSN/ISBN: 0368-2781 PMID: 2391758 Document Number: 353044
We studied clinical effects of norfloxacin (NFLX, AM-715) tables. The results we found are summarized as follows: 1. Ten patients with 5 diseases were mediated with 7.0 .apprx. 14.8 mg/kg of the drug 3 times daily for 6 .apprx. 8 days. They consisted of one-each with tonsilitis, pharyngitis, bronchitis, 4 with Campylobacter enteritits, 3 with other enteritis. Clinical responses to the treatment were excellent in 8, good in 1 and fair in 1, with an efficacy rate of 90%. Bacteriologically, of 9 isolates for which changes in populations were followed, 6 were eradicated and 3 remained unchanged, with an eradication rate of 66.7%. 2. No adverse reactions nor abnormal laboratory test values attributable to the drug were observed. 3. These results suggest that new quinolone drug may be useful, against bacterial infections in children 6 years and older.